Table 2.

Performance of selected metabolites among HC, CC and RC groups

	HC versus CC			HC versus RC			CC versus RC
	Training set	Ten-fold cross validation	Test set	Training set	Ten-fold cross validation	Test set	Training set	Ten-fold cross validation	Test set
AUC (95%CI)	0.9543(0.9274–0.9813)	0.9373(0.8988–0.9759)	0.9173(0.8274–1.0000)	0.9168(0.8800–0.9536)	0.9027(0.8567–0.9487)	0.8566(0.7447–0.9685)	0.8221(0.7590–0.8852)	0.8005(0.7342–0.8668)	0.8182(0.6894–0.9470)
Sensitivity	0.8642	0.8395	0.9000	0.7614	0.8068	0.8182	0.7159	0.7273	0.8636
Specificity	0.9340	0.9057	0.8462	0.9151	0.8491	0.8077	0.8272	0.8025	0.8000
Accuracy	0.9037	0.8717	0.8478	0.8402	0.8247	0.8125	0.7633	0.7574	0.8095
Kappa statistic	0.8028	0.7371	0.6922	0.6735	0.6458	0.6237	0.5286	0.5161	0.6182
P-value for kappa statistic	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001

HC, healthy control; CC, colon cancer; RC, rectal cancer; AUC, area under receiver-operating characteristic curve; CI, confidence interval.