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. Author manuscript; available in PMC: 2025 Oct 30.
Published in final edited form as: J Physiol. 2024 Oct 3;603(20):5903–5919. doi: 10.1113/JP286469

Fig. 2. Ube3A and Ube3B regulate presynaptic pruning and function.

Fig. 2.

A) Summary of Ube3A function in mammalian neurons. Ube3A promotes excitatory synaptic transmission, and inhibits clathrin-coated vesicle accumulation in inhibitory neurons. B) At the fly NMJ, Ube3A promotes synaptic pruning via polyubiquitination and inhibition of Tkv thereby restricting a Tkv/Mad signaling axis. C) In rodents, Ube3B (a paralog of Ube3A) promotes Synapsin I levels in excitatory neurons and restricts VGAT levels in inhibitory neurons. This suggests Ube3B could influence excitatory and inhibitory presynaptic function. Ube3B polyubiquitinates the BCKDK kinase and Ppp3cc phosphatase subunit, but it is unclear if Ube3B functions through these molecular mechanisms to influence presynaptic transmission.