Table 2.
Algorithm Implementation and Deviations Leading to Non-Adherence
| Algorithm implementation | |||
| BZD-responsive (n = 34) | BZD-resistant (n = 26) | p Values | |
| BCH algorithm implementation, n (%) | 14 (41) n = 34 | 0 (0) n = 26 | <0.001a |
| AES algorithm implementation, n (%) | 22 (65) n = 34 | 4 (15) n = 26 | <0.001a |
| Personalized SAP implementation, n (%) | 10 (50), n = 20 | 4 (29), n = 14 | 0.296a |
| Deviations from algorithms leading to nonadherence (%) | ||||
| Delayed time (>25) | Incorrect dose (> ±25) | Incorrect order | >1 deviation | |
| Lack of implementation of BCH algorithm (n = 46) n (%) | 43 (93) | 25 (54) | 23 (50) | 30 (65) |
| Lack of implementation of AES algorithm (n = 34) n (%) | 18 (53) | 26 (76) | 20 (59) | 21 (62) |
| Lack of implementation of personalized SAP (n = 20) n (%) | 20 (100) | 0 (0) | 9 (45) | 9 (45) |
Abbreviations: AES = American Epilepsy Society; ASM = antiseizure medication(s); BCH = Boston Children's Hospital; BZD = benzodiazepine.
a
Fisher exact test.