Table 3.

Clinical Outcomes Based on Algorithm and SAP Implementation

Variables	Personalized SAP implementation (n = 14)	Personalized SAP nonimplementation (n = 20)	p Value	BCH algorithm implementation (n = 14)	BCH algorithm nonimplementation (n = 46)	p Value	AES algorithm implementation (n = 26)	AES algorithm nonimplementation (n = 34)	p Value
Total seizure duration, median (p25–p75) (min)	9 (6–16) n = 14	22 (11–64) n = 20	<0.01a	7 (5–10) n = 14	33 (17–68) n = 46	<0.001a	10 (6–16) n = 26	45 (22–85) n = 34	<0.001a
Time to first ASM, median (p25-p75) (min)	5 (4–5) n = 14	16 (6–31) n = 20	<0.001a	5 (5-5) n = 14	15 (6–28) n = 44	<0.001a	5 (5–9) n = 25	17 (7–37) n = 33	<0.001a
Time to s ASM, median (p25–p75) (min)	10 (8–19) n = 5	17 (9–35) n = 15	0.203a	8 (7–9) n = 3	25 (11–49) n = 32	<0.05a	9 (8–15) n = 8	31 (17–55) n = 27	<0.05a
Time to third ASM, median (p25–p75) (min)	24 (13–31) n = 4	39 (23–77) n = 9	0.105a	n = 0	39 (26–77) n = 25	—	29 (22–42) n = 4	42 (30–81) n = 21	0.159a
ICU admission ratec, n (%)	6 (46) n = 13	12 (71) n = 17	0.264b	5 (36) n = 14	27 (66) n = 41	0.064b	10 (43), n = 23	22 (69), n = 3	0.096b
ICU LOS median (p25–p75) (d)	3 (2–8) n = 6	3 (1–5) n = 12	0.538a	2 (1–4) n = 5	2 (1–5) n = 27	0.752a	1 (1–4) n = 10	3 (1–6) n = 22	0.208a
Intubation rated, n (%)	2 (14) n = 14	10 (53) n = 19	<0.05b	1 (7) n = 14	20 (45) n = 44	<0.05b	4 (17), n = 24	17 (50) n = 34	<0.05b

Abbreviations: ASM = antiseizure medication; ICU = intensive care unit; LOS = length of stay.

^aMann-Whitney U test.

^bFisher exact test.

^cICU admission because of CSE.

^dIntubation because of CSE.