Table 3.
Cox proportional hazards regression model analysis for outcome risks in ischemic HFmrEF patients
| Variable | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) |
P-value | Wald | Hazard ratio (95% CI) |
P-value | |
| ALL CAUSE DEATH | |||||
| Age per year | 1.06 (1.05, 1.07) | < 0.0001 | 112.9 | 1.05 (1.03, 1.06) | < 0.0001 |
| Log NT-proBNP | 1.46 (1.35, 1.58) | < 0.0001 | 87.44 | 1.16 (1.06, 1.26) | 0.0013 |
| Anaemia | 2.68 (2.17, 3.31) | < 0.0001 | 82.92 | 1.65 (1.28, 2.12) | < 0.0001 |
| PCI | 0.32 (0.25, 0.41) | < 0.0001 | 75.67 | 0.48 (0.36, 0.64) | < 0.0001 |
| Renal dysfunction | 2.27 (1.82, 2.83) | < 0.0001 | 52.97 | 1.22 (0.94, 1.57) | 0.1348 |
| Hyperuricaemia | 2.03 (1.63, 2.53) | < 0.0001 | 40.18 | 1.37 (1.07, 1.75) | 0.0137 |
| COPD | 2.04 (1.58, 2.65) | < 0.0001 | 29.07 | 1.26 (0.93, 1.69) | 0.1315 |
| NYHA class IV/III vs. II | 1.82 (1.45, 2.29) | < 0.0001 | 26.86 | 1.20 (0.93, 1.54) | 0.165 |
| Stroke | 1.97 (1.52, 2.55) | < 0.0001 | 26.19 | 1.76 (1.33, 2.33) | < 0.0001 |
| Atrial fibrillation | 1.71 (1.32, 2.21) | < 0.0001 | 16.7 | 1.23 (0.93, 1.63) | 0.148 |
| Hypertension | 1.68 (1.30, 2.17) | < 0.0001 | 15.41 | 1.08 (0.82, 1.42) | 0.5922 |
| T2DM | 1.42 (1.15, 1.76) | 0.0012 | 10.49 | 1.50 (1.18, 1.91) | 0.0009 |
| Hyperlipidemia | 0.64 (0.48, 0.86) | 0.0026 | 9.08 | 0.78 (0.57, 1.08) | 0.1312 |
| Current smoker | 0.77 (0.61, 0.97) | 0.0254 | 4.99 | 1.17 (0.90, 1.51) | 0.2407 |
| Male vs. Female | 0.91 (0.73, 1.13) | 0.3917 | 0.73 | ||
| Body mass index | 0.99 (0.97, 1.02) | 0.5095 | 0.44 | ||
| CARDIOVASCULAR EVENT | |||||
| Log NT-proBNP | 1.23 (1.17, 1.28) | < 0.0001 | 66.81 | 1.13 (1.08, 1.19) | < 0.0001 |
| Anaemia | 1.52 (1.33, 1.74) | < 0.0001 | 37.55 | 1.19 (1.02, 1.39) | 0.0293 |
| Age per year | 1.02 (1.01, 1.02) | < 0.0001 | 35.47 | 1.01 (1.00, 1.02) | 0.0026 |
| Hyperuricaemia | 1.53 (1.32, 1.77) | < 0.0001 | 31.89 | 1.34 (1.14, 1.58) | 0.0004 |
| Renal dysfunction | 1.52 (1.31, 1.76) | < 0.0001 | 30.25 | 1.03 (0.86, 1.22) | 0.7712 |
| Atrial fibrillation | 1.43 (1.20, 1.70) | < 0.0001 | 16.54 | 1.32 (1.09, 1.59) | 0.0042 |
| Hypertension | 1.34 (1.16, 1.56) | < 0.0001 | 15.37 | 1.19 (1.01, 1.40) | 0.0403 |
| PCI | 0.77 (0.67, 0.88) | 0.0001 | 15.13 | 0.99 (0.85, 1.15) | 0.8570 |
| NYHA class IV/III vs. II | 1.26 (1.10, 1.43) | 0.0008 | 11.34 | 1.03 (0.89, 1.20) | 0.6916 |
| COPD | 1.35 (1.12, 1.63) | 0.0016 | 9.96 | 1.19 (0.97, 1.46) | 0.099 |
| T2DM | 1.24 (1.08, 1.42) | 0.0018 | 9.71 | 1.29 (1.11, 1.49) | 0.0009 |
| Stroke | 1.31 (1.09, 1.58) | 0.0043 | 8.14 | 1.19 (0.97, 1.45) | 0.0902 |
| Current smoker | 0.85 (0.74, 0.98) | 0.0216 | 5.28 | 0.99 (0.85, 1.17) | 0.9497 |
| Hyperlipidemia | 0.90 (0.76, 1.06) | 0.1872 | 1.74 | ||
| Body mass index | 0.99 (0.97, 1.01) | 0.2291 | 1.45 | ||
| Male vs. Female | 0.93 (0.81, 1.06) | 0.2793 | 1.17 | ||
Bold represent significant values (p < 0.05). abbreviations can be found in Table 1