Table 5. Inclusion and exclusion criteria for the STROGHAT clinical trial.

	Inclusion criteria	Exclusion criteria
1	Able to give signed informed consent (assent for adolescents)	Individuals with a positive parasitological exam on the spot at baseline
2	Both sexes	Participants previously treated for g-HAT or previously treated because of gHAT seropositive results
3	11 years of age or older and weight ≥30 kg	Pregnant women
4	CATT or RDT test positive	Breast-feeding women
5	Able to ingest oral tablets	Children ≥11 years but under 30kg body weight
6	Known address and/or contact details provided	Clinically significant medical condition
7	Able to comply with the schedule of follow-up visits and other study requirements	Jaundice
8	Agree not to take part in any other clinical trials during the participation in the clinical trial	Participants who are taking, or who are expected to need to start within 4 months, a medicine (including traditional or herbal) which may interact with acoziborole and which cannot be stopped or adjusted

Only individuals complying with all the inclusion criteria can participate in the STROGHAT nested clinical trial. Presence of one of the exclusion criteria excludes participation in the study.