Table 6. Chance of detecting one adverse event with various real incidences and sample sizes.

Real incidence (%)	Sample size	Chance of detecting at least one event
0.1% (1/1000)	900	59%
0.1%	1150	69%
0.1% *	1245	71%
0.1%	1500	77%
0.1%	1610	80%
0.1%	2000	86%
0.1%	2500	92%
0.1%	3000	95%
0,13% * (1,3/1000)	1245	80%
0.2% (2/1000)	900	83.5%
0.5% (5/1000)	900	98.9%
1% (10/1000)	900	99.99%

The Table illustrates what is the chance of detecting at least one adverse events with various disease incidences and sample sizes. * Corresponds to the current number of individuals exposed to acoziborole. The incidence is set at 0.13% to reach a 80% chance of detecting an event.