Table 4.
Minimum inhibitory/effective concentrations (mg/L) of ARAf (N = 143) against five different antifungal agents
| AMB | ITR | MGX* | OLO | VCZ | |
|---|---|---|---|---|---|
| GM# | 0.540 | 10.664 | 0.018 | 0.029 | 4.747 |
| Range | 0.125–2 | 0.5–> 8 | 0.08–0.06 | 0.008–0.125 | 0.25–> 8 |
| MIC50/MEC50 | 0.5 | > 8 | 0.016 | 0.03 | 4 |
| MIC90/MEC90 | 1 | > 8 | 0.03 | 0.06 | > 8 |
AMB, Amphotericin B; ITR, Itraconazole; GM, Geometric mean; MGX, Manogepix; MEC50, Minimum effective concentration for at least 50% of strains; MEC90, Minimum effective concentration for at least 90% of strains; MIC50, Minimum inhibitory concentration for at least 50% of strains; MIC90, Minimum inhibitory concentration for at least 90% of strains; OLO, Olorofim; VCZ, Voriconazole. *MEC was determined for MGX. #When no detectable antifungal activity was observed at 8 mg/L a value of 16 mg/L was used to calculate the GM