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. 2025 Apr 5;15:11692. doi: 10.1038/s41598-025-96003-9

Table 2.

Existing literature: contributions and research gaps.

Ref Dataset Methodology Optimization Technique Accuracy Research Gap
32 UCI Heart Disease HyOPTXGBoost and HyOPTRF Optuna Optimization 94.2% Lack of interpretability
33 Cleveland Supervised ML Algorithms Traditional ML 92.8% Limited feature selection optimization
34 Framingham Hybrid XGBoost with Optuna tuning Hyperparameter tuning 96.1% High sensitivity to outliers
35 MIT-BIH Arrhythmia ML algorithms Feature Selection 93.7% Computationally expensive
36 UCI Heart Disease Genetic Algorithm GA 95.3% High training time
37 ECG-based Dataset CNN-LSTM CNN-LSTM 92.4% High computational cost
38 Custom CVD Dataset Deep Reinforcement Learning for heart disease detection DRL 90.9% Slow convergence
39 UCI Heart Disease Gradient-Based Optimizer GBO 95.1% Sensitive to parameter selection
40 ECG-based Dataset Rime Optimization Algorithm for ECG-based detection RIME 91.7% High computational cost
41 MIT-BIH Dataset Heap-Based Optimizer (HBO) for ML-based heart disease detection HBO 93.2% Lack of interpretability