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. Author manuscript; available in PMC: 2025 Jun 1.
Published in final edited form as: J Expo Sci Environ Epidemiol. 2024 Oct 6;35(3):478–485. doi: 10.1038/s41370-024-00723-5

Table 2:

Adjusted cumulative incidence ratios (CIR) and 95% confidence intervals (CIs) for the association between PFAS drinking water contamination and U.S. county-level COVID-19 cumulative mortality (1/20/2020–12/11/2020)

Model Primary independent variable Sample size CIR
[95% CI]

Statewide sampling dataa Detection above 5 ng/L 621 1.12 [1.04, 1.19]
Detection above lowest state-level MCLb 621 1.15 [1.07, 1.23]

UCMR 3c Detection above UCMR 3 reporting limits 1677 1.13 [1.08, 1.19]

Results are from quasi-Poisson regressions that included an offset for total population and random intercepts for state, county-level sociodemographic factors (% non-Hispanic Black residents, % Hispanic residents, % non-Hispanic White residents, % residents over age 65, % residents with less than a high school education, % homeowners, log of median household income, log of median owner-occupied household value), total hospital beds, the number of days since the first case in the county, and population density.

a

The statewide sampling dataset comprises sampling campaigns from 18 states with PFAS samples collected between 2017–2020.

b

This refers to concentrations above the lowest state-level Maximum Contaminant Levels (MCL) as of October 2022.

c

The UCMR 3 was a nationwide survey of unregulated contaminants (including PFAS) conducted by the US EPA in 2013–2015.