Fig. 4.

Insula activity predicts peripheral measures of inflammatory potential and lung function. Percent signal change in the left insula in response to As compared with Ne words [As - Ne] and percentage of EOS during late-phase antigen relative to methacholine challenge [Ag - Meth] (a)(r = 0.99, P < 0.001) and peak fall FEV₁ during late phase antigen [Ag] challenge (b) (r = -0.97, P < 0.01). Note that clusters in a and b were identified independently and are not identical, although they largely overlap. For analyses with FEV₁, only values for the Ag challenge were used because one participant was missing data from the Meth challenge.