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. Author manuscript; available in PMC: 2025 Apr 7.
Published in final edited form as: J Proteome Res. 2024 Sep 9;23(10):4392–4408. doi: 10.1021/acs.jproteome.4c00363

Figure 7: Assessment of quantitative results using median normalization and batch correction of inter-batch external QC samples.

Figure 7:

(Top panel or 7A) The effect of median normalization and batch correction of peptide and protein coefficient of variance (CV) from all the pooled lumbar CSF inter-batch external QC samples within each plate (batch). The median coefficient of variation (η) is indicated by the dashed red line. (Bottom panel or 7B) The effect of median normalization and batch correction of peptide and protein coefficient of variance from all the pooled lumbar CSF inter-batch external QC samples from all plates. The relationship between coefficient of variation and the log2 median abundance is visualized with a LOESS fit of a contoured density plot (red line).