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. 2025 Mar 25;16:1539934. doi: 10.3389/fphar.2025.1539934

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Copyright © 2025 An, Wang, Qin, Cheng, Bai, Cheng, Xu and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PEITC reduced the mRNA levels of pyroptosis-related proteins in mice with liver injury induced by triptolide. (A) Relative expression of Nlrp3 mRNA in liver tissues. (B) Relative expression of Casp1 mRNA in liver tissues. (C) Relative expression of Gsdmd mRNA in liver tissues. (D) Relative expression of Il1b mRNA in liver tissues. The data are presented as the means ± SEMs (n = 6 per group). ^## P < 0.01, ^### P < 0.001 vs. the normal group; ^** P < 0.05, ^** P < 0.01, ^** P < 0.001 vs. the triptolide control.