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. 2025 Mar 25;16:1539934. doi: 10.3389/fphar.2025.1539934

FIGURE 4.

FIGURE 4

PEITC prevented hepatocyte pyroptosis in mice with liver injury induced by triptolide. (A) Immunoblot analysis of NLRP3, pro-Caspase-1, cleaved Caspase-1, GSDMD, GSDMD-N, the IL-1β precursor, mature IL-1β and Tubulin. (B–H) The relative protein levels of pro-Caspase-1/Tubulin, cleaved Caspase-1/Tubulin, GSDMD-N/GSDMD, GSDMD/Tubulin, NLRP3/Tubulin, the IL-1β/IL-1β precursor, and mature IL-1β/Tubulin. The data are presented as the means ± SEMs (n = 6 per group). ## P < 0.01, ### P < 0.001 vs. the normal group; ** P < 0.05, ** P < 0.01, ** P < 0.001 vs. the triptolide control.