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. 2024 Aug 9;30(12):3482–3494. doi: 10.1038/s41591-024-03011-9

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© The Author(s) 2024, corrected publication 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a, Cell clustering in each group based on integrated snATAC-seq and snRNA-seq analyses. b, Expression pattern of the cell proliferation marker MKI67. c, ESR1 expression showed genetic ancestry-dependent variability with a subpopulation of LASP cells in Indigenous Americans expressing ESR1. d, ESR1 gene chromatin accessibility patterns in LHS, LASP and BM cells of various genetic ancestry groups, and BRCA1 and BRCA2 mutation carriers. e, FOXA1 expression and FOXA1 gene chromatin accessibility patterns in several genetic ancestry groups, and BRCA1 and BRCA2 mutation carriers. f, GATA3 expression and chromatin accessibility patterns in several genetic ancestry groups, and BRCA1 and BRCA2 mutation carriers. g, ELF5 expression and chromatin accessibility patterns in several genetic ancestry groups, and BRCA1 and BRCA2 mutation carriers. The red vertical box shows a chromatin-accessible peak unique to the cells of the BRCA2 mutation carrier. h, EHF expression and chromatin accessibility patterns in several genetic ancestry groups, and BRCA1 and BRCA2 mutation carriers.