Table 1. Implementation of the PICOS strategy.

Population	Patients undergoing orthodontic treatment with fixed appliances or aligners, without age, sex or background restrictions.
Intervention	Surgical and non-surgical techniques for acceleration of orthodontic tooth movement.
Comparison	Control groups (e.g., no intervention group, contralateral tooth/teeth groups), baseline conditions, or distinct acceleration methods.
Results	Velocity/amount of tooth movement, biological effects of acceleration techniques on the periodontium.
Study design	Randomized controlled trials.