Table 3.

Summary of the different regions of chromosomal aberration between non-response and response group.

Chromosome	Region	R(H)/S(L)	R(L)/S(H)	Accession	Start	Stop	Gene symbol	NCBI gene ID	Name
2	2q37.2	√		NC_000002.12	234,682,668	234,717,764	LINC01173	106,144,537	Long intergenic non-protein coding RNA 1173
4	4q32.1		√	Noncoding gene
5	5q12.3		√	NC_000005.10	64,768,918	65,018,763	CWC27	10,283	CWC27 spliceosome associated cyclophilin
10	10q21.3		√	NC_000010.10	67,672,281	69,455,953	CTNNA3	29,119	Catenin alpha 3
	10q31.32	√		Noncoding gene
11	11p11.2		√	Noncoding gene
	11q13.3	√		Noncoding gene
	11q14.2		√	NC_000011.10	86,672,237	86,753,297	ME3-DT	107,984,427
	11q14.1(2)	√		NC_000011.10	78,652,829	79,441,030	TENM4	26,011	Teneurin transmembrane protein 4
16	16p11.2		√	NC_000011.9	31,453,948	31,531,169	IMMP1L	196,294	Inner mitochondrial membrane peptidase subunit 1
	16q22.3	√		NC_000011.9	73,386,683	73,472,119	RAB6A	5870	RAB6A, member RAS oncogene family
	16q23.3	√		NC_000016.10	82,626,823	83,800,640	CDH13	1012	Cadherin 13
17	17q22		√	NC_000017.10	57,785,015	57,919,616	VMP1	81,671	Cacuole membrane protein 1
21	21q21.3		√	Noncoding gene
22	22q12.3		√	NC_000022.10	36,956,904	37,099,797	CACNG2	10,369	Calcium voltage-gated channel auxiliary subunit gamma 2

Chromosomal aberrations were analyzed by MetaboAnalyst program with Log 2 Ratio. A high Log 2 Ratio in was demonstrated in the non-response group, but low in the response group in the following locations: chromosome 2 (2q37.2), 10 (10q31.32), 11 (11q13.3, 11q14.1) and 16 (16q22.3, 16q23.3), Log 2 Ratio in the non-response group was low, but high in the response group in the following locations: chromosome 4 (4q32.1), 5 (5q12.3), 10 (10q21.3), 11 (11p11.2, 11q14.2), 16 (16p11.2), 17q (17q22), 21 (21q21.3) and 22 (22q12.3).