Figure 1.

Visualisation of REST-targeted DEGs and enrichment analysis of REST-targeted upregulated DEGs in DS hiPSC-derived astrocytes. (A) Depiction of the overlap between REST target genes and the upregulated DEGs in DS iPSC-derived astrocytes. The hypergeometric test determined the statistical analysis of the gene overlap, and a p-value <0.01 is considered statistically significant. (B) Depiction of the overlap between REST target genes and the downregulated DEGs in DS iPSC-derived astrocytes. (C) Biological processes and (D) KEGG pathways for REST-targeted upregulated DEGs in DS iPSC-derived astrocytes. (E) Depiction of astrocyte reactive markers in the overlap between REST target genes and all DEGs (including upregulated and downregulated DEGs) in DS iPSC-derived astrocytes.