Table 2.

HR (95% CI) for outcomes across groups of Klotho levels

	Model 1			Model 2			Model 3
Klotho	HR (95% CI)	P-value		HR (95% CI)	P-value		HR (95% CI)	P-value
Continuous	1.00 (1.00, 1.00)	0.0050		1.00 (1.00, 1.00)	0.3898		1.00 (1.00, 1.00)	0.2573
Q1	1.0			1.0			1.0
Q2	0.66 (0.53, 0.81)	< 0.0001		0.68 (0.55, 0.84)	0.0003		0.71 (0.57, 0.88)	0.0017
Q3	0.65 (0.53, 0.80)	< 0.0001		0.75 (0.60, 0.92)	0.0068		0.94 (0.75, 1.16)	0.5434
Q4	0.65 (0.53, 0.80)	< 0.0001		0.80 (0.65, 0.99)	0.0384		0.97 (0.78, 1.20)	0.7533
P for trend		0.0003			0.0576			0.8030

Model 1: did not adjust for any confounding factors

Model 2: adjusted for age, gender, race

Model 3: adjusted for age, gender, race, PIR, Marital status, Smoking, Alcohol status, eGFR, Hypertension, Coronary heart disease

Footnote klotho levels quartile (Q): Q1:≤645.7; Q2:646.8–802.8; Q3:803- 1008.9; Q4:≥1009.5

Abbreviations: PIR, poverty income ratio; eGFR, estimated glomerular filtration rate; HR, hazard ratio; CI, confidence interval