Fig. 2.

Spatial multi-omics profiling of HCC upon nivolumab treatment. A Characterization of ST-seq data by cell-type deconvolution, H&E staining, and unsupervised clustering. B t-SNE visualization of ST-seq spots colored by regions. C Dot plot of average expression for selected marker genes in each region. D Heatmap of Hallmark pathway (from MSigDB) activities scored per region by ssGSEA. E Spatially mapped feature-level ssGSEA scores for selected Hallmark gene sets. Color scale represents enrichment scores