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. 2025 Apr 9;24:110. doi: 10.1186/s12943-025-02314-w

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — Lipid accumulation, spatial distance between TAM and CD8, and drug response. A Dot plot showing pathway enrichment of lipogenesis and lipolysis in the NR group. B Oil red O staining in representative cases of the R (lower panel; 60% and 96% of tumor necrosis) and NR (upper panel; 15% and 30% of tumor necrosis) groups. C Scatter plot of the expression of genes related to lipid synthesis using qPCR analysis. D Correlation diagram between the expression of genes related to lipid synthesis and percentage of tumor necrosis. E Spatial visualization of CD8^Rel spots and TAM^Rel spots in representative cases of the R and NR groups. F Box plot showing the statistical comparison of the spatial distance between CD8^Rel and TAM^Rel spots between the R and NR groups. G Alluvial diagram showing the composition of enriched TAM, enriched CD8, and TAM/CD8 spots in the R and NR groups. H Conceptual diagram showing the derivation of heterotypic and homotypic scores. I Box plot showing the statistical comparison of heterotypic score (TAM^Rel to CD8^Rel, with TAM^Rel serving as the center point) between the R and NR groups. J Spatial visualization of TAM^Rel and CD8^Rel as spatial neighborhoods in representative cases of the R and NR groups. K Box plot showing the statistical comparison of the functional scores of CD8^Rel surrounding TAM^Rel between the R and NR groups. L. Box plot showing the statistical comparison of homotypic scores of TAM^Rel and CD8^Rel between the R and NR groups. M Spatial visualization of the homotypic scores of TAM^Rel and CD8^Rel between R and NR groups. N Ripley's L diagram showing TAM^Rel and CD8^Rel distribution patterns (dispersed or clustered) between R and NR groups