Fig. 7.

Intense communication among TAM, tumor cells and T cells to elicit pro-tumorigenic consequences in relation to nivolumab response. A Dot plot showing the interactions of immune checkpoint ligand-receptor pairs (left panel). Each row represents a cell–cell interaction pair, and each column represents a ligand-receptor pair. Chord diagram showing significant immune checkpoint ligand-receptor pairs between R and NR groups (right panel). B Chord diagram showing significant ligand-receptor pairs via CellphoneDB, with enriched tumor spots as the receiver between R and NR groups. C Dot plot showing significant ligand-receptor pair between the R and NR groups, with enriched tumor spots as the receiver. Each row represents a ligand-receptor pair and each column represents a sender-receiver pair. D A schematic representation of the molecular and cellular axis in the R group. E Spatial visualization of cell type distribution (column in far left), monocular expression, and communication signal strength, with the multiple small black arrows showing the directions of the communication signal trend