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. 2025 Apr 3;17(1):2480666. doi: 10.1080/19420862.2025.2480666

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© 2025 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — Mixtures of HALA antibodies with enhanced FcγRIIa activity and blocking antibodies maximize activity and selectivity while minimizing tradeoffs. (a-b) The fold activation of FcγRIIa (ADCP reporter cells) for mixtures of wild-type trastuzumab with enhanced Fc2 (wt-eFc2) and different ratios of a blocking antibody corresponding to (a) HER2⁺⁺⁺ and (b) HER2⁺ cells, as well as (c) the ratio of HER2⁺⁺⁺/HER2⁺ activities. (d-e) The fold activation for mixtures of S12-eFc2 with different ratios of the blocking antibody corresponding to (d) HER2⁺⁺⁺ and (e) HER2⁺ cells, as well as (f) the ratio of activities. (g-h) The fold activation for mixtures of S4-eFc2 with different ratios of the blocking antibody corresponding to (g) HER2⁺⁺⁺ and (h) HER2⁺ cells, as well as (i) the ratio of activities. (j-l) Comparison of the maximum activities relative to the maximum selectivities for (j) wt-eFc2:blocker mixtures, (k) S12-eFc2:blocker mixtures and (l) S4-eFc2:blocker mixtures. In (a-l), the data are averages of three independent experiments, and the error bars are standard errors. In (k-l), the gray data and line correspond to the wt-eFc2:blocker data shown in (j).