Table 1.
Protein families with known biological functions in tick saliva.
| Biological function | Protein family | Examples |
|---|---|---|
| Anticoagulants | Enzymes | Apyrase, 5’-Nucleotidase |
| Kunitz-domain containing proteins | Ixolaris, Tissue factor pathway inhibitor (TFPI)-like proteins | |
| Lipocalins | Histamine and leukotriene-binding proteins | |
| Chemokine and Cytokine modulators | Evasins | Evasin 1, 3, 4 |
| Serpins | Iris, IRS-2, Iripin-1 | |
| Cystatins | Sialostatin L, Sialostatin L2 | |
| Lipocalins | Histamine and leukotriene-binding proteins | |
| Enzymes | DNases/RNases, Prostaglandin E2 synthase, Adenosine deaminase-like proteins | |
| Complement Inhibitors | I. scapularis salivary proteins | ISAC, Salp-20 |
| I. ricinus salivary proteins | IRAC I and II | |
| Serpins | Iripin-5 and 8 | |
| Structural proteins | Cement proteins | Glycine- and proline-rich proteins |
| Mucin-like proteins | ||
| Host interaction proteins | Tick receptor | Tick receptor for OspA (TROSPA) |
| I. scapularis salivary proteins | Salp15 | |
| Miscellaneous Families | Antimicrobial peptides | |
| Heat shock proteins | ||