Table 3.

Putative effects of tick saliva components on blood vessels, nerve fibers and extracellular matrix (ECM) in the skin.

Blood vessels	Nerve fibers	ECM
Inhibition of angiogenesis	Suppression of nociception	Inhibition of wound healing
Damage of endothelial integrity	Inhibition of neurotransmitters	Altered degradation of extracellular matrix proteins
Inhibition of thrombin-regulated vessel modulations	Degradation of pain mediators	Dysregulated extracellular matrix remodeling
Increased vascular permeability	Counteraction of endocannabinoid-induced immunosuppression	Impaired keratinocyte migration