Table 4.
Univariate and multiple logistic regression analysis to identify predictors of a 4-point increase in patients with and without the condition.
| Variable | Univariate | Multiple | ||
|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | |
| The age at the initiation of treatment | ||||
| Cohort A | 1.00 | – | – | – |
| Cohort B | 0.297 (0.086–1.025) | 0.055 | – | – |
| Cohort C | 0.174 (0.046–0.656) | 0.010 | – | – |
| Cohort D | 0.083 (0.022–0.318) | <0.001 | – | – |
| Cohort E | 0.035 (0.009–0.138) | <0.001 | – | – |
| Gender | ||||
| Female | 1.00 | – | – | – |
| Male | 1.666 (0.997–2.782) | 0.051 | – | – |
| SMN copies | ||||
| 2 copies | 1.00 | – | – | – |
| 3 copies | 0.383 (0.046–3.163) | 0.383 | – | – |
| Types of SMA | ||||
| Type 1a | 1.00 | - | – | – |
| Type 1b | 1.480 (0.866–2.531) | 0.152 | – | – |
| Type 1c | 3.538 (1.182–10.587) | 0.024 | – | – |
| Pre-treatment respiratory | ||||
| 24-h | 1.00 | – | – | – |
| Spontaneous | 7.000 (4.000–12.250) | <0.001 | – | – |
| Pre-treatment feeding | ||||
| Oral | 1.00 | – | 1.00 | |
| Tube | 0.132 (0.067–0.261) | <0.001 | 0.244 (0.117–0.505) | <0.001 |
| Gastrostomy | 0.070 (0.034–0.144) | <0.001 | 0.176 (0.080–0.391) | <0.001 |
| CHOP-INTEND score, at baseline | 1.148 (1.104–1.193) | <0.001 | 1.106 (1.061–1.153) | <0.001 |
OR, Odds ratio; CI, confidence intervals. Bold values indicate statistically significant (p-value < 0.05). Omnibus test chi-square test = 100.971, p-value < 0.001; Hosmer and Lemeshow test = 5.006, p-value = 0.757 and Nagelkerke R2 = 0.405.