Table 6. Top 20 DNA methylation regions significant differences between 12 months following supplementation and baseline.
| Chr | Start position | End position | Width | Number of CpG sites | Overlapping genes | Mean differential | Min smoothed FDR | HMFDR |
| chr5 | 179224563 | 179226186 | 1624 | 12 | MGAT4B, MIR1229 | 0.0378 | 1.24E-39 | 5.21E-19 |
| chr16 | 69140794 | 69141478 | 685 | 11 | HAS3 | −0.0063 | 1.73E-18 | 4.04E-12 |
| chr17 | 43972306 | 43973522 | 1217 | 10 | MAPT, MAPT-AS1 | −0.0134 | 1.26E-22 | 5.53E-12 |
| chr2 | 65659148 | 65660700 | 1553 | 12 | SPRED2 | −0.0151 | 2.12E-18 | 3.62E-11 |
| chr16 | 56965376 | 56966475 | 1100 | 12 | HERPUD1 | −0.0041 | 2.63E-17 | 4.52E-11 |
| chr22 | 19466331 | 19467326 | 996 | 15 | CDC45, UFD1L | −0.0059 | 5.39E-23 | 7.43E-11 |
| chr10 | 1033582 | 1035006 | 1425 | 15 | GTPBP4, AL359878.1 | −0.0049 | 1.28E-14 | 9.76E-11 |
| chr4 | 2964097 | 2965549 | 1453 | 15 | GRK4, NOP14 | −0.0105 | 4.96E-19 | 1.42E-10 |
| chr11 | 105947676 | 105949106 | 1431 | 23 | AASDHPPT, KBTBD3 | −0.0053 | 1.03E-16 | 1.47E-10 |
| chr4 | 75859212 | 75860346 | 1135 | 6 | PARM1 | −0.0858 | 8.28E-18 | 2.22E-10 |
| chr7 | 75795555 | 75796528 | 974 | 7 | −0.0152 | 6.79E-16 | 1.02E-09 | |
| chr3 | 15468722 | 15469386 | 665 | 12 | EAF1, METTL6 | −0.0113 | 9.94E-18 | 1.18E-09 |
| chr16 | 11438416 | 11439785 | 1370 | 13 | RMI2, RP11-485G7.5 | −0.0106 | 3.38E-14 | 2.33E-09 |
| chr12 | 58165256 | 58166652 | 1397 | 16 | METTL21B, METTL1 | −0.0096 | 5.30E-15 | 3.78E-09 |
| chr2 | 180871638 | 180872164 | 527 | 14 | CWC22 | −0.0654 | 2.33E-30 | 5.67E-09 |
| chr11 | 65728931 | 65729635 | 705 | 9 | SART1 | −0.0053 | 4.52E-11 | 1.19E-08 |
| chr11 | 94822598 | 94823603 | 1006 | 6 | ENDOD1 | −0.0084 | 1.29E-18 | 1.44E-08 |
| chr14 | 100070556 | 100071437 | 882 | 9 | RP11-543C4.1 | −0.0118 | 1.26E-12 | 2.79E-08 |
| chr17 | 79633202 | 79633857 | 656 | 15 | CCDC137, OXLD1 | −0.0068 | 1.47E-09 | 3.64E-08 |
| chr15 | 63333846 | 63335016 | 1171 | 8 | TPM1 | −0.0080 | 3.75E-15 | 3.89E-08 |
The regions are annotated by their chromosomal location (chr), their start and end base pair position, and the number of base pairs they span (width). The number of differentially methylated CpG sites with each region as well as the genes overlapping these regions (when applicable) are also detailed. All regions with a positive mean differential coefficient are hypermethylated regions while regions with negative mean differential coefficients are hypomethylated. The last two columns list the minimum smoothed false discovery rate (FDR), and the Holm-adjusted FDR (HMFDR) which was used to determine significance.