Table 5.
Parameters of the De Pittà model (De Pittà and Berry, 2019).
| Parameters of De Pittà model | ||
|---|---|---|
| Parameter | Value | Description |
| c0 | 10.0 μM | Total [Ca2+] in terms of cytosolic vol |
| ν1 | 7.759 s−1 | Maximal Ca2+ release rate by IP3Rs |
| ν2 | 0.01 s−1 | Ca2+ leak rate |
| O2 | 0.325 μM−1 s−1 | Ca2+ leak rate |
| k3 | 0.1 μM | Ca2+ affinity of SERCA pumps |
| ν3 | 10.0 μMs−1 | Maximal Ca2+ uptake rate |
| d1 | 0.1 μM | IP3 |
| d2 | 4.5 μM | Ca2+ (inhibition) |
| d3 | 0.1 μM | IP3 |
| d5 | 0.05 μM | Ca2+ (activation) |
| c1 | 0.5 | ER-to-cytoplasm volume ratio |
| Oβ | 0.141 μMs−1 | Maximal rate of IP3 production by PLCβ |
| ΓA | 1.0 | Fraction of bound receptors |
| Oδ | 0.05 μMs−1 | Maximal rate of IP3 production by PLCδ |
| Kδ | 0.5 μM | Ca2+ affinity of PLCδ |
| kδ | 1.0 μM | Inhibiting IP3 affinity of PLCδ |
| Ω5P | 0.86 s−1 | Rate of IP3 degradation by IP-5P |
| O3K | 0.163 μMs−1 | Maximal rate of IP3 degradation by IP33K |
| K3K | 1.0 μM | IP3 affinity of IP33K |
| KD | 0.5 μM | Ca2+ affinity of IP33K |