Table 2.
Impact of Dula (50, 100, and 150 μg/kg) on oxidative stress biomarkers (TAC, GSH, SOD, and MDA)
| Parameters | Groups | ||||||
|---|---|---|---|---|---|---|---|
| Control | Dula control | AA | SLZ+AA | Dula 50 μg/kg + AA | Dula 100 μg/kg + AA | Dula 150 μg/kg + AA | |
| TAC | 0.7038 ± 0.03586 | 0.7165 ± 0.02442 | 0.3425 ± 0.03312$ | 0.6677 ± 0.03928λ | 0.5010 ± 0.03562$λϕ | 0.5944 ± 0.02876λ | 0.6829 ± 0.02002λ∇ |
| GSH | 4.487 ± 0.1466 | 4.092 ± 0.1073 | 1.011 ± 0.1022$ | 3.141 ± 0.2640$λ | 1.688 ± 0.1445$ϕ | 2.248 ± 0.2036$λϕ | 2.881 ± 0.2421$λ∇ |
| SOD | 492.6 ± 14.82 | 445.8 ± 5.121 | 250.4 ± 17.58$ | 424.3 ± 14.45λ | 317.2 ± 23.02$ϕ | 352.8 ± 18.15$λϕ | 417.0 ± 15.34$λ∇ |
| MDA | 69.31 ± 4.532 | 70.70 ± 4.638 | 304.8 ± 19.22$ | 97.61 ± 5.359λ | 177.7 ± 15.64$λϕ | 146.9 ± 12.45$λ | 115.6 ± 9.130λ∇ |
Data were expressed as mean ± SEM (n = 8)
Dula dulaglutide, AA acetic acid, SLZ sulfasalazine, TAC total antioxidant capacity, MDA malondialdehyde, GSH reduced glutathione, SOD superoxide dismutase
$,λ,ϕ,∇p<0.05, significantly different from the control group, AA-injected group, SLZ-treated group, and Dula 50 μg/kg-injected group, respectively, using one-way ANOVA followed by Tukey-Kramer multiple comparisons post hoc test