. 2025 Mar 26;311(4):1111–1125. doi: 10.1007/s00404-025-07996-7

Table 3.

Logistic regression analyses for investigation of impact of pre-operative characteristics on risk for failure of treatment. OR (95% CI)

Pre-operative parameter	^aNo permanent pain reduction (n = 28/110, 25.5%)	^bGC not improved (n = 37/122, 30.3%)	^cInfertility not overcome (n=29/62, 46.8%)	^dReoperation (n=25/122, 20.5%)
Age per year	0.933 (0.876–0.993) p = 0.029	1.041 (0.989–1.095) p=0.124	1.169 (1.051–1.301) p=0.004	0.995 (0.940–1.054) p=0.873
Obesity (BMI > 30)	0.637 (0.195–2.085) p = 0.456	0.774 (0.278–2.154) p=0.624	2.652 (0.610–11.519) p=0.193	0.525 (0.143–1.932) p=0.332
Smoking	2.011 (0.814–4.963) p = 0.130	0.624 (0.287–1.358) p=0.235	0.796 (0.278–2.285) p=0.672	1.353 (0.553–3.307) p=0.507
Higher education	1.765 (0.737–4.230) p = 0.202	1.239 (0.555–2.768) p=0.601	0.519 (0.176–1.532) p=0.235	0.872 (0.341–2.228) p=0.775
Physical acitivity ≥ 1x weekly	0.640 (0.270–1.518) p = 0.311	0.747 (0.342–1.629) p=0.463	1.926 (0.653–5.682) p=0.235	2.048 (0.784–5.351) p=0.144
Permanent partnership	0.417 (0.141–1.229) p = 0.113	0.571 (0.199–1.640) p=0.298	0.460 (0.103–2.056) p=0.309	0.565 (0.179–1.786) p=0.331
rASRM-Score I vs. IV	1.796 (0.589–5.471) p=0.303	1.571 (0.524–4.711) p=0.420	0.606 (0.158–2.319) p=0.464	1.080 (0.296–3.946) p=0.907
rASRM-Score II vs. IV	0.735 (0.163–3.308) p=0.688	1.786 (0.519–6.141) p=0.358	0.909 (0.158–2.319) p=0.901	1.687 (0.422–6.743) p=0.459
rASRM-Score III vs. IV	1.071 (0.289–3.973) p=0.918	2.551 (0.794–8.192) p=0.116	1.515 (0.286–8.032) p=0.625	2.224 (0.607–8.144) p=0.228
CPP	3.869 (1.071–13.981) p=0.039	0.724 (0.322–1.626) p=0.434	1.235 (0.410–3.720) p=0.708	7.407 (1.651–33.239) p=0.009
Dysmenorrhoe	1.213 (0.237–6.215) p=0.817	0.281 (0.100–0.784) p=0.015	0.481 (0.081–2.862) p=0.421	1.341 (0.356–5.051) p=0.664
Dispareunia	0.691 (0.288–1.661) p=0.409	0.440 (0.200–0.967) p=0.041	0.909 (0.310–2.669) p=0.862	3.321 (1.152–9.569) p=0.026
Hypermenorrhoe	1.270 (0.535–3.015) p=0.588	0.830 (0.383–1.800) p=0.637	1.635 (0.573–4.660) p=0.358	1.733 (0.709–4.238) 0.228
Infertility	1.472 (0.615–3.525) p=0.386	0.646 (0.297–1.406) p=0.271	–	0.709 (0.293–1.716) p=0.445
^gCOC*	1.500 (0.413–5.450) p=0.538	2.133 (0.671–6.779) p=0.199	–	3.818 (0.936–15.579) p=0.062
^hProgestin*	0.857 (0.314–2.337) p=0.763	0.731 (0.298–1.795) p=0.495	–	2.567 (0.815–8.082) p=0.107
pre-operative NRS pain score per point	0.968 (0.944–0.992) p=0.009	0.978 (0.965–0.992) p = 0.002	1.002 (0.981–1.024) p = 0.829	1.041 (1.011–1.072) p = 0.008

Pre-operative parameter

^aNo permanent pain reduction (n = 28/110, 25.5%)

^bGC not improved (n = 37/122, 30.3%)

^cInfertility not overcome (n=29/62, 46.8%)

^dReoperation (n=25/122, 20.5%)

Age per year

0.933 (0.876–0.993)

p = 0.029

1.041 (0.989–1.095)

p=0.124

1.169 (1.051–1.301)

p=0.004

0.995 (0.940–1.054)

p=0.873

Obesity (BMI > 30)

0.637 (0.195–2.085)

p = 0.456

0.774 (0.278–2.154)

p=0.624

2.652 (0.610–11.519)

p=0.193

0.525 (0.143–1.932)

p=0.332

Smoking

2.011 (0.814–4.963)

p = 0.130

0.624 (0.287–1.358)

p=0.235

0.796 (0.278–2.285)

p=0.672

1.353 (0.553–3.307)

p=0.507

Higher education

1.765 (0.737–4.230)

p = 0.202

1.239 (0.555–2.768)

p=0.601

0.519 (0.176–1.532)

p=0.235

0.872 (0.341–2.228)

p=0.775

Physical acitivity ≥ 1x weekly

0.640 (0.270–1.518)

p = 0.311

0.747 (0.342–1.629)

p=0.463

1.926 (0.653–5.682)

p=0.235

2.048 (0.784–5.351)

p=0.144

Permanent partnership

0.417 (0.141–1.229)

p = 0.113

0.571 (0.199–1.640)

p=0.298

0.460 (0.103–2.056)

p=0.309

0.565 (0.179–1.786)

p=0.331

rASRM-Score I vs. IV

1.796 (0.589–5.471)

p=0.303

1.571 (0.524–4.711)

p=0.420

0.606 (0.158–2.319)

p=0.464

1.080 (0.296–3.946)

p=0.907

rASRM-Score II vs. IV

0.735 (0.163–3.308)

p=0.688

1.786 (0.519–6.141)

p=0.358

0.909 (0.158–2.319)

p=0.901

1.687 (0.422–6.743)

p=0.459

rASRM-Score III vs. IV

1.071 (0.289–3.973)

p=0.918

2.551 (0.794–8.192)

p=0.116

1.515 (0.286–8.032)

p=0.625

2.224 (0.607–8.144)

p=0.228

CPP

3.869 (1.071–13.981)

p=0.039

0.724 (0.322–1.626)

p=0.434

1.235 (0.410–3.720)

p=0.708

7.407 (1.651–33.239)

p=0.009

Dysmenorrhoe

1.213 (0.237–6.215)

p=0.817

0.281 (0.100–0.784)

p=0.015

0.481 (0.081–2.862)

p=0.421

1.341 (0.356–5.051)

p=0.664

Dispareunia

0.691 (0.288–1.661)

p=0.409

0.440 (0.200–0.967)

p=0.041

0.909 (0.310–2.669)

p=0.862

3.321 (1.152–9.569)

p=0.026

Hypermenorrhoe

1.270 (0.535–3.015)

p=0.588

0.830 (0.383–1.800)

p=0.637

1.635 (0.573–4.660)

p=0.358

1.733 (0.709–4.238)

0.228

Infertility

1.472 (0.615–3.525)

p=0.386

0.646 (0.297–1.406)

p=0.271

–

0.709 (0.293–1.716)

p=0.445

^gCOC*

1.500 (0.413–5.450)

p=0.538

2.133 (0.671–6.779)

p=0.199

–

3.818 (0.936–15.579)

p=0.062

^hProgestin*

0.857 (0.314–2.337)

p=0.763

0.731 (0.298–1.795)

p=0.495

–

2.567 (0.815–8.082)

p=0.107

pre-operative NRS pain score per point

0.968 (0.944–0.992)

p=0.009

0.978 (0.965–0.992)

p = 0.002

1.002 (0.981–1.024)

p = 0.829

1.041 (1.011–1.072)

p = 0.008

CPP chronic pelvic pain. Bold numbers indicate statistical significance (p ≤ 0.05)

^aFailure in permanent pain reduction was assumed if individual improvement of NRS Score at time of interview was lower than 20 points compared to pre-operative value. Median time between surgery and interview was 6 years (range 4.3–7.8). Only patients with a pre-operative NRS Score of > 20 were included

^bPatients who answered “no” when questioned “Do you think your quality of life has improved after surgery?”, GC subjective general condition

^cNo live birth after endometriosis surgery in patients with infertility before treatment

^dNeed for repeated endometriosis surgery

^gCombined oral contraceptives

^hOral progestin or hormonal intrauterine device

^*two patients were excluded who had bilateral adnexectomy and subsequent HRT with pure estradiol