Table 5.

Univariate and multivariate analysis of the association between sub-categories of various receptors and overall survival. A p-value of <0.05 was considered significant. Overall survival relative to the indicated features was determined by Cox regression analysis.

Expression in Years	Univariate			Multivariate
	Hazard Ratio	95% CI	p-Value	Hazard Ratio	95% CI	p-Value
HER2 Intensity 1+	0.665	0.398–1.111	0.119	0.677	0.403–1.137	0.140
HER2 ≥ 5%	0.567	0.331–0.970	0.038	0.556	0.323–0.958	0.034
HER2 ≥ 50%	0.608	0.332–1.114	0.107	1.37	0.910–2.081	0.130
HER2 Cytoplasmic	0.612	0.354–1.056	0.078	0.650	0.373–1.132	0.128
HER2/HER4 ≥ 5%	0.669	0.414–1.083	0.102	0.706	0.433–1.151	0.162
HER2/EGFRVIII ≥ 5%	0.670	0.413–1.089	0.106	0.710	0.435–1.158	0.170
HER2/CD44 ≥ 5%	0.669	0.398–1.122	0.128	0.687	0.405–1.164	0.163
HER2/HER4/EGFRVIII ≥ 5%	0.686	0.686–1.098	0.116	0.718	0.445–1.156	0.173
HER2/HER4/EGFRVIII/CD44 ≥ 5%	0.678	0.424–1.085	0.105	0.702	0.436–1.133	0.147