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. 2025 Apr 7;14:433–449. doi: 10.2147/ITT.S502925

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© 2025 Yang et al.

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rAT reduced pulmonary inflammation in LPS-induced ARDS model mice. (A–D) The levels of inflammatory factors, including IL-6 (A), TNF-α (B), IL-8 (C), and hs-CRP (D), were decreased in the serum of the rAT-treated group, as detected by ELISA. (E) Immunohistochemical staining for F4/80 revealed that rAT treatment reduced the proportion of macrophages in the lung tissue of LPS-induced ARDS model mice. (F) Immunohistochemical staining for MRCI, a marker of M2 macrophages, showed that rAT treatment increased the proportion of M2 macrophages in the lung tissue of LPS-induced ARDS model mice. (G) Immunohistochemical staining for Ly6G, a marker of neutrophils, showed that rAT treatment reduced the proportion of neutrophils in the lung tissue of LPS-induced ARDS model mice. All the data are presented as the means ± SDs of three independent experiments. One-way ANOVA, *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant; scale bar, 50 μm.