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. 2025 Apr 7;14:433–449. doi: 10.2147/ITT.S502925

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© 2025 Yang et al.

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The activity of IL17a signaling pathway were inhibited by rAT. (A) The top 20 GO terms from the results of GO enrichment analysis of the DEGs obtained from model mice treated with or without rAT in the GSE33690 dataset. (B) The top 20 signaling pathways from the results of KEGG enrichment analysis of the DEGs obtained from model mice treated with or without rAT in the GSE33690 dataset. (C) The results of GSEA showed that IL17a signaling pathway were inhibited after the treatment of rAT in LPS-induced ARDS mice. (D) The expression of IL17a in LPS-induced lung injury tissues was significantly reduced following treatment with rAT, as evidenced by data from the GSE33690 dataset. The data are expressed as the means ± SDs (n=3 in each group); Student’s t test, **p < 0.01. (E) The mRNA expression of IL17a in LPS-induced lung injury tissues was significantly downregulated after treatment with rAT, as measured by real-time PCR. One-way ANOVA, ****p < 0.0001. (F) The protein expression of IL17a in LPS-induced lung injury tissues was significantly reduced following treatment with rAT, as confirmed by Western blot analysis. The data are expressed as the means ± SDs (n=3 in each group). One-way ANOVA, ***p < 0.001 and ****p < 0.0001.