15d-PGJ2 |
15-deoxy-Δ12,14-prostaglandin J2 |
5-FU |
fluorouracil |
AF |
activation function |
AgRC |
agonist–receptor complex |
AnRC |
antagonist–receptor complex |
AIF |
apoptosis-inducing factor |
ALT |
alanine aminotransferase |
ALPI |
alkaline phosphatase |
AMPK |
AMP-activated protein kinase |
AP1 |
activator protein 1 |
BAX |
BCL2-associated X protein |
Bcl |
B-cell lymphoma proteins (Bcl-2 and Bcl-xL) |
BRAF |
B-rapidly accelerated fibrosarcoma |
BRCA1 |
breast cancer gene 1 |
cAMP |
cyclic adenosine monophosphate |
CAF |
cancer-associated fibroblasts |
CASP1 |
caspase 1 |
CAT |
catalase |
CBP |
CREB-binding protein |
CCL2 |
C-C motif chemokine ligand 2 |
CCND1 |
cyclin D1 |
CD |
complex of differentiation |
CDK5 |
cyclin-dependent kinase 5 |
c-FLIP |
flice-inhibitory protein |
CHK2 |
checkpoint kinase 2 |
CGZ |
ciglitazone |
CNS |
central nervous system |
CCND1 |
cyclin D1 |
COX2 |
cyclooxygenase 2 |
CTL |
cytotoxic lymphocyte |
CTLA |
cytotoxic T-lymphocyte antigen |
CXCL12 |
C-X-C motif chemokine ligand 12 |
DBD |
DNA-binding domain |
DC |
dendritic cell |
DHA |
docosahexanoic acid |
DOPA |
3,4-dihydroxyphenylalanine |
DOPA enzyme |
tyrosine hydroxylase |
DR |
death receptor |
DTIC |
dacarbazine |
ECM |
extracellular matrix |
EFZ |
multidrug resistance 1 |
EGF |
epidermal growth factor |
EGFR |
epidermal growth factor receptor |
eIF2 |
eukaryotic initiation factor 2 |
EPA |
eicosopentanoic acid |
ERK1/2 |
extracellular signal-regulated kinases ½ |
FABP4 |
fatty acid-binding protein 4 |
FAK |
focal adhesion kinase |
FDA |
Food and Drug Administration |
FOS |
this protein name originates from Finkel–Biskis–Jinkins (FBJ) murine osteosarcoma virus |
GPX |
glutathione peroxidase |
GSK-3β |
glycogen synthase kinase-3β |
HCC |
hepatocellular carcinoma |
HDAC3 |
histone deacetylase 3 |
HIF1 α |
hypoxia-inducible factor 1α |
HMOX1 |
heme oxygenase-1 |
IFNG |
interferon γ |
IGF1 |
insulin-like growth factor 1 |
IGFBP3 |
insulin growth factor-binding protein 3 |
IGF1 |
insulin growth factor 1 |
IKK-α |
inhibitor of nuclear factor κB kinase subunit α |
JNK |
c-Jun N-terminal kinase |
JUN |
this protein name originates from “ju-nana”, the Japanese word for “17”,じゅうなな, (e.g., a viral oncogene v-jun means the seventeenth viral oncogene in English) |
KLRG1 |
killer cell lectin-like receptor subfamily G member 1 |
LAG3 |
lymphocyte-activation gene 3 |
LBD |
ligand-binding domain |
LC-PUFA |
long-chain polyunsaturated fatty acid |
LXR |
liver X receptor |
MAPK |
mitogen-activated protein kinase |
MC1R |
melanocortin-1 receptor |
MCAD1 |
medium-chain acyl-CoA dehydrogenase |
MDR1 |
multidrug resistance 1 |
MDSC |
myeloid-derived suppressor cell |
MHC1 |
major histocompatibility complex class I |
MITF |
microphthalmia-associated transcription factor |
α-MSH |
α-melanocyte-stimulating hormone |
mTOR |
mechanistic target of rapamycin |
NCoA |
nuclear receptor coactivator |
NCoR |
nuclear receptor corepressor |
NFκB |
nuclear factor κB |
NRF2 |
nuclear factor erythroid 2-related factor 2 |
NSCLC |
non-small cell lung cancer |
NYHA |
New York Heart Association |
Octa |
2,4,6-octatrienoic acid |
O-GlcNAc |
β-O-linked N-acetylglucosamine |
p70S6K |
p70 ribosomal S6 kinase |
PDGF |
platelet-derived growth factor |
PDK4 |
pyruvate dehydrogenase kinase 4 |
PD-L1 |
programmed death ligand 1 |
PERK |
protein kinase RNA-like endoplasmic reticulum kinase |
PGC-1α |
PPAR-γ coactivator-1α |
PGC-1β |
PPAR-γ coactivator-1β |
PGZ |
pioglitazone |
PI3K |
phosphoinositide 3-kinase |
PKA |
protein kinase A |
PKB |
protein kinase B |
PKC |
protein kinase C |
PKR |
protein kinase RNA-activated |
PLA2 |
phospholipase A2 |
PLC |
phospholipase C |
PPAR-α |
peroxisome proliferator-activated receptor α |
PPAR-β/δ |
peroxisome proliferator-activated receptor β/δ |
PPAR-γ |
peroxisome proliferator-activated receptor γ |
PPRE |
peroxisome proliferator response element |
PTEN |
phosphatase and tensin homolog deleted on chromosome 10 |
PUFA |
polyunsaturated fatty acid |
RB1 |
retinoblastoma 1 |
RGZ |
rosiglitazone |
ROS |
reactive oxygen species |
RXR- α |
retinoid X receptor α |
SHC |
Src homology and collagen |
SMAD2 |
mothers against decapentaplegic homolog 2 |
SMRT |
silencing mediator of retinoid and thyroid hormone receptors |
SNP |
single-nucleotide polymorphism |
SOD |
superoxide dismutase |
SRC |
sarcoma family member |
STAT3 |
signal transducer and activator of transcription 3 |
T2D |
type 2 diabetes |
TAM |
tumor-associated macrophage |
TetO |
tetracycline operator |
TGF-β |
transforming growth factor-β |
TIM3 |
T-cell immunoglobulin and mucin domain-3 |
TME |
tumor microenvironment |
TNF-α |
tumor necrosis factor-α |
TP53 |
tumor protein p53 |
TRAIL |
TNF-related apoptosis-inducing ligand |
Treg |
regulatory T cell |
TRPM1 |
transient receptor potential melastatin 1 |
TRP1 |
tyrosinase-related protein-1 |
TRP2 |
tyrosinase-related protein-2 |
TZD |
thiazolidinedione |
TYR |
tyrosinase |
VCAM1 |
vascular cell adhesion molecule 1 |
VDR |
vitamin D receptor |
VEGF |
vascular endothelial growth factor |
VILL1 |
villin 1 |
WNT |
wingless-related integration site |