There is increased AP-IR in subacute and chronic lesions of pneumonia, and the AP-IR is especially prominent in the cytoplasm of hyperplastic cells. (A) Hyperplastic bronchiolar epithelium 15 days p.i. with bacteria. Intense cytoplasmic AP-IR is present in cuboidal epithelial cells. Magnification, ×40. (B) Bronchioles 15 days p.i. with bacteria. In the cytoplasm of hyperplastic epithelial cells in this focus of bronchiolitis fibrosa obliterans, there is intense AP-IR. Magnification, ×40. (C) Bronchioles 45 days p.i. with bacteria are lined by cuboidal, hyperplastic epithelial cells, and many have intense cytoplasmic AP-IR. Magnification, ×20.