Figure 7. Percentage of PBMCs from scrapie-infected sheep reactive with C-terminal-specific anti-PrP monoclonal antibodies.

Ovine PBMCs from VRQ homozygous sheep were collected at various time points following oral inoculation with scrapie brain material and analysed by flow cytometry with anti-PrP monoclonal antibodies V468 (●), V26 (▲) or A516 (■) as described in the Materials and methods section. n=6 for months 3–5 p.i.; n=3 for months 6–7 p.i.; and n=2 for month 8 p.i. Results are shown as means±S.D.