Table 1.

Categories of Interventions for AIMSS

Major category or subcategory	Definition
Pharmacological interventions
Endocrine or hormonal	Medication interventions acting on an endocrine system and/or by suppressing, enhancing, or otherwise altering the release or activity (or supplementing) hormones. This category includes bisphosphonates in addition to more traditionally defined endocrine interventions.
Analgesic or anti-inflammatory	Medication interventions acting directly on pain perception at the level of nociception including anti-inflammatory interventions as well as opioid and non-opioid analgesics. The latter includes NSAIDs, COX-2 inhibitors, and corticosteroids.
Neuromodulatory	The interventions for this review are centrally- and peripherally acting medications, not classified as direct analgesics or anti-inflammatory agents, that alter nerve impulse transmission. These include CNS-active medications (antidepressants, anticonvulsants, gabapentinoids, cannabinoids, etc) and peripherally applied pharmaceutics (capsaicin, botulinum toxin, topical preparations, etc).
Therapeutic switching to alternative AI	Switching from one AI to a different AI, with or without an interim washout period.
Combination	Two or more interventions from the pharmacological intervention sub-categories above (including within the same sub-category) administered simultaneously.
Other pharmacological	Medication interventions not included among the above sub-categories.
Complementary/alternative interventions
Nutritional or dietary supplements	This sub-category includes herbs/botanicals, vitamins and minerals, probiotics, and dietary supplements.
Traditional medicine	This sub-category includes traditional Chinese medicine, homeopathy, naturopathy, Ayurvedic medicine, and the use of traditional healers.
Physiological or psychophysiological	This sub-category includes tai chi, yoga, acupuncture, massage therapy, musculoskeletal manipulation, qigong, relaxation techniques, and hypnotherapy.
Combination	Two or more interventions from the complementary/alternative intervention sub-categories above (including within the same sub-category) administered simultaneously.
Other complementary/alternative	Complementary/alternative interventions not included among the above sub-categories
Rehabilitative interventions
Supervised sport or exercise	Supervised sports activities or exercise in any form, excluding interventions classified as complementary/alternative.
Physio-/occupational/recreational therapy	Formal physical therapy, occupational therapy, or recreational therapy intervention(s).
Psychosocial/educational	Psychological or educational interventions, excluding interventions classified as complementary/alternative.
Combination	Two or more interventions from the rehabilitative intervention sub-categories above (including within the same sub-category) administered simultaneously.

Abbreviations: AI, aromatase inhibitor; COX-2, cyclooxygenase-2; NSAID, non-steroidal anti-inflammatory medication.