TABLE 3.
HP0638 frame status of H. pylori isolates that induce either high or low levels of IL-8
| Country and H. pylori isolates | Strain | IL-8 inductiona (pg/ml) | HP0638 frame status | P-Tyrb |
|---|---|---|---|---|
| United States cagA+vacAs1m1 isolates | ||||
| High IL-8 inducers | 97-141 | 1,936 | In | + |
| 97-31 | 2,023 | In | + | |
| 97-511 | 2,381 | In | + | |
| 97-112 | 2,452 | In | + | |
| 95-58 | 2,898 | In | + | |
| Low IL-8 inducers | 98-238 | 265 | In | + |
| 95-79 | 305 | Out | − | |
| 96-32 | 350 | In | − | |
| 96-62 | 362 | In | + | |
| 96-71 | 620 | Out | + | |
| cagA negative vacAs2m2 isolates | ||||
| J188 | 290 | Out | − | |
| J292 | 366 | Out | − | |
| Japan, cagA+vacAs1m1 isolates | ||||
| High IL-8 inducers | 98-15 | 2,051 | In | + |
| 98-30 | 2,053 | In | + | |
| 98-14 | 2,081 | In | + | |
| 98-46 | 2,123 | In | + | |
| 98-40 | 2,590 | In | + | |
| Low IL-8 inducers | 98-32 | 151 | In | − |
| 98-36 | 287 | In | + | |
| 98-37 | 287 | In | + | |
| 98-33 | 335 | In | + | |
| 98-28 | 574 | In | + |
a
IL-8 levels in supernatants from AGS cells cocultured with specified H. pylori isolates; means from duplicate determinations.
b
Presence of tyrosine-phosphorylated CagA protein within epithelial cells, determined as described in Materials and Methods (+, present; −, absent).