Table 3.
Type I error (%) of falsely including a variability parameter that was not simulated for the two sampling schemes (a: 0.5, 2, 8, 22 h after dose, b: 0, 0.5, 2, 8, 22 h after dose) and two magnitudes of IOV (25%, 75%) on parameters CL, V and ka
| Sampling | OCC | SIM/EST with IIVonly | |||||
|---|---|---|---|---|---|---|---|
| EST with IOVCL | EST with IOVV | EST with IOVka | |||||
| 25% | 75% | 25% | 75% | 25% | 75% | ||
| type I error [%] | type I error [%] | type I error [%] | type I error [%] | type I error [%] | type I error [%] | ||
| a | 1 | 1.4 | 0.4 | 1.6 | 1.8 | 0.2 | 0.0 |
| a | 2 | 0.8 | 0.8 | 1.8 | 0.8 | 1.6 | 1.0 |
| a | 3 | 0.4 | 0.4 | 2.0 | 1.4 | 1.0 | 3.0 |
| b | 1 | 4.6 | 5.2 | 0.8 | 1.8 | 0.0 | 0.0 |
| b | 2 | 0.4 | 1.4 | 0.6 | 0.8 | 2.0 | 0.8 |
| b | 3 | 1.4 | 2.0 | 0.6 | 1.4 | 1.0 | 0.8 |