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. 2025 Apr 11;20:174. doi: 10.1186/s13023-025-03682-8

Table 2.

Pulmonary function and motor status in patients with spinal muscular atrophy and severe scoliosis before and after scoliosis surgery

Case no Sex SMA type Age of scoliosis onset (years) Age of scoliosis surgery (years) Follow-up duration (months) Preoperative FVC(mL) Postoperative FVC (mL, 6-months) Postoperative FVC (mL, last follow-up) Changes in FVC (last follow-up) Preoperative motor status Postoperative motor status (6-months) Postoperative motor status (last follow-up) Changes in motor status (last follow-up)
1 F 2 7 13 36 1210 1430 1400 Improved Sit with support Sit with support Sit with support Static
2 F 3 4 17 72 630 720 650 Improved Independent sit Independent sit Independent sit Static
3 F 2 7 17 43 520 480 510 Worsened Sit with support Independent sit Independent sit Improved
4 F 2 6 20 31 810 760 640 Worsened Sit with support Independent sit Independent sit Improved
5 M 2 9 13 30 2620 2480 2740 Improved Sit with support Independent sit Independent sit Improved
6 F 2 9 23 27 540 630 610 Improved Sit with support Independent sit Independent sit Improved
7 M 2 10 16 31 1260 1150 1060 Worsened Sit with support Sit with support Sit with support Static
8 F 2 4 12 43 1090 1140 1210 Improved Independent sit Independent sit Independent sit Static
9 F 2 8 11 38 640 530 570 Worsened Sit with support Independent sit Independent sit Improved
10 F 3 2 13 44 890 950 920 Improved Sit with support Independent sit Independent sit Improved
11 M 3 3 18 36 1250 1180 1040 Worsened Sit with support Sit with support Sit with support Improved
12 F 3 7 13 27 800 630 580 Worsened Sit with support Independent sit Independent sit Improved
13 F 3 6 20 31 1560 1320 1410 Worsened Sit with support Independent sit Independent sit Improved
14 F 3 9 13 24 1780 1840 1890 Improved Sit with support Sit with support Sit with support Static
15 M 2 5 12 42 880 960 980 Improved Sit with support Independent sit Independent sit Improved
16 F 2 9 17 42 820 780 850 Improved Sit with support Independent sit Independent sit Improved
17 F 2 6 11 32 720 860 970 Improved Sit with support Independent sit Independent sit Improved
18 M 3 15 22 56 2920 2780 2720 Worsened Independent sit Independent sit Independent sit Static
19 F 2 7 15 31 1510 1360 1630 Improved Sit with support Independent sit Independent sit Improved
20 M 2 8 15 66 880 740 550 Worsened Sit with support Independent sit Independent sit Improved
21 M 2 9 26 48 1960 1850 1720 Worsened Sit with support Independent sit Independent sit Improved
22 F 3 4 17 56 990 840 740 Worsened Independent sit Independent sit Independent sit Static

F, female; FVC, forced vital capacity; M, male; SMA, spinal muscular atrophy