Table 4.
HLA-DR Associations with Selected Autoimmune Diseases among 256 White Multiplex Autoimmune Families[Note]
|
DR-Allele Frequency (%a) in |
|||
| Disease (No. of Individuals) and DR Allele | Cases | Controls | OR (95% CI)b |
| RA (129): | |||
| DR4 | 58 | 28 | 2.02 (1.62–2.42) |
| SLE (107): | |||
| DR2 | 35 | 29 | 1.2 (.91–1.59) |
| DR3 | 45 | 20 | 2.24 (1.75–2.87) |
| MS (135): | |||
| DR2 | 53 | 29 | 1.84 (1.54–2.24) |
| AITD (270): | |||
| DR3 | 38 | 20 | 1.89 (1.58–2.30) |
| T1D (65): | |||
| DR3 | 57 | 20 | 2.89 (2.24–3.65) |
| DR4 | 69 | 28 | 2.44 (2.0–2.96) |
Note.— DR typing results are shown by use of serologic equivalence. DR2 contains both DRB1*15 and DRB1*16 alleles, and DR4 contains all DRB1*04 subtypes.
a
Frequency (%) is rounded to the nearest integer.
b
Compared with a group of 926 white controls from the New York metropolitan area.