Table 3.
Multivariate associations between explicative factors and ABPA in people with cystic fibrosis from the French CF Registry.
| Odds ratio | 95% confidence interval | P-value | |
|---|---|---|---|
| Nutritional status, BMI | |||
| BMI (continuous) | 0.94 | [0.89; 1.00] | .0412 |
| Low (<18.5) vs. normal (18.5–24.9) | 1.05 | [0.70; 1.58] | .8121 |
| High (>25) vs. normal (18.5–24.9) | 0.47 | [0.24; 0.95] | .0365 |
| Glucose disorder vs. none | 1.41 | [1.02; 1.93] | .0353 |
| Respiratory status | |||
| ppFEV1 (continuous) | 1.00 | [1.00; 1.01] | .7745 |
| ppFEV1 < 40% vs. ≥ 70% | 0.75 | [0.40; 1.40] | .3619 |
| ppFEV1 40%–70% vs. ≥ 70% | 0.90 | [0.61; 1.34] | .5994 |
| Pseudomonas aeruginosa colonization vs. none | 1.31 | [0.90; 1.89] | .1575 |
| Therapy for advanced pulmonary disease (oxygen or NIV) vs. none | 1.75 | [0.83; 3.67] | .1384 |
| Number of annual intravenous antibiotic courses | |||
| 1–3 vs. 0 | 1.69 | [1.19; 2.39] | .0033 |
| >3 vs. 0 | 2.47 | [1.21; 5.05] | .0132 |
| Long-term inhaled corticosteroids | 1.82 | [1.33; 2.48] | .0002 |
| Long-term azithromycin | 1.24 | [0.92; 1.67] | .1644 |
| Antifungal treatment | 5.83 | [2.55; 13.35] | <.0001 |
Note: Significant P-values are in bold.
BMI: body mass index, ppFEV1: predicted forced expiratory volume in 1 s, NIV: noninvasive ventilation.