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. 2005 Feb 24;76(4):623–633. doi: 10.1086/429391

Figure 4.

Figure 4

Schematic diagram of the DNA sequences, splicing events, and translated proteins for the p46, p48, and p52 isoforms. A, p46, generated from the G allele at the splice-acceptor site SNP (hCV2567433). B, p52 and p48, generated from the A allele at splice-site SNP. C, Exon 7 translated amino acid sequences for p46, p48, and p52. SNPs rs3177979, rs1051042, and rs2660 are within codons of the underlined amino acids. For p46, rs2660 is untranslated; the splice-site G allele is in linkage disequilibrium with allele G at rs3177979 and allele G at rs1051042, producing amino acids A (GCA) and R (AGG), respectively. For p48, rs3177979 and rs1051042 are untranslated; splice-site allele A is in disequilibrium with allele A at rs2660, producing amino acid R (AGA). For p52, splice-site allele A is in disequilibrium with alleles A, C, and A at the three SNPs, producing amino acids V (GTA), R (CGT), and K (AAG), respectively.