FIG. 4.

TCR repertoire in patient MZ-CC01-3. (A) TCR VA and VB analysis in PBL, tumor, and TIL. Note that only a limited number of TCR VB chains are present in CD4⁺ TIL. (B) TCR perturbation analysis in tumor tissue compared to PBL or TIL. There are no major differences in regard to the TCR VA or VB composition in tumor tissue compared to PBL. (C) TCR perturbation analysis in CD4⁺ TIL compared to CD4⁺ PBL or tumor tissue. Note the overrepresentation of a selected number of TCR VA or VB chains in TIL. This CD4⁺ TIL line showed recognition of autologous tumor cells (Table 3). Asterisks indicate monoclonal TCRs. aa, amino acids.