Table 1.

Results of Genomewide Scan and Additional Genotyping on Chromosome 12^[Note]

	No. of Families Used		No. of Subjects Genotyped		LOD Score at Markera
Scoring Function and Data Set	As OriginallyPresented	After Split	Affected	Unaffected	D1S1677	D5S408	D7S559	PAH
Shomoz, with overrelated individuals	44	47	144	55	1.59	1.15	1.67	3.11
Shomoz, without overrelated individuals	41	43	130	48	1.40	.92	2.20	3.45
Sall, with overrelated individuals	40	43	140	51	2.93	2.80	.09	3.11
Sall, without overrelated individuals	37	39	126	44	2.77	2.41	.09	3.28
Shomoz, with overrelated individuals, with additional genotyping	46	49	160	60	…	…	…	4.61
Shomoz, without overrelated individuals, with additional genotyping	43	45	143	53	…	…	…	5.20
Sall, with overrelated individuals, with additional genotyping	43	46	157	56	…	…	…	3.51
Sall, without overrelated individuals, with additional genotyping	40	42	140	49	…	…	…	3.64

Note.— Regions achieving LOD scores ⩾2 in at least one analysis. Shown are results with the S_homoz or S_all scoring function, including or excluding the individuals “corrected” for overrelatedness, and, for chromosome 12, including additional genotyping.

^aThe scores presented are exactly at the marker listed for D1S1677, D5S408, and D7S559. In the case of PAH, the score shown is exactly at the marker when S_homoz is used; when S_all is used, however, the score shown is the largest in the region, which was found between D12S1041 (104.12 cM) and PAH (109.47 cM) in the genomewide scan and between PAH and D12S78 (111.87 cM) when extra markers were added to this region.