Table A2.

Number of Various Types of Genotyped Affected Pairs^[Note]

	No. of Pairs (No. after Removal of Overrelated Individuals)
Pair Type	Outbred	Inbred
Genomewide scan:
Parent-child, related parents	NA	16
Full-sibling	20	31 (23)
Half-sibling	1	0
Avuncular	12	15 (14)
Grandparent-grandchild	1	11
Grand-avuncular	1	2
Double first cousin	0	8
First cousin + more distant cousin	0	3
First cousin	5	24 (11)
First cousin once-removed	2	10
Second cousin	1	4
More distant cousin	3	2
For additional chromosome 12 markers:
Parent-child, related parents	NA	17 (16)
Full-sibling	21	34 (26)
Half-sibling	1	0
Avuncular	12	21 (20)
Grandparent-grandchild	1	13 (11)
Grandavuncular	1	5
Double first cousin	0	9
First cousin + more distant cousin	0	3
First cousin	5	28 (14)
First cousin once removed	2	10
Second cousin	1	4
More distant cousin	3	2

Note.— Numbers of informative, affected, genotyped pairs in the family structures that were split for linkage analysis and “corrected” for overrelatedness. Also, in parentheses, the numbers of informative, affected, genotyped pairs in the family structures that were split for linkage analysis and had the overrelated individuals removed (only when they were different). Affected pairs with more than one relationship were classified by their closest relationship, except in the case of first cousins. First-cousin pairs were subdivided by the relationship (if any) induced through the two parents not involved in the initially identified first-cousin relationship. Inbred pairs included at least one member with related parents or grandparents. For the whole genome-scan, 56 individuals with related parents (54 after overrelated individuals were removed) were also available for analysis; for additional markers on chromosome 12, 59 individuals with related parents (57 after overrelated individuals were removed) were also available for analysis. NA = not applicable.