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. 2024 Oct 11;20(2):811–818. doi: 10.1016/j.jds.2024.09.021

Figure 2.

Figure 2

Poly(I:C) attenuated the expression of apoptosis-related proteins in the aortic plaques induced by P. gingivalis in APOE-/-mice. (Black scale:100 μm). P. gingivalis increases the expression of pro-apoptotic proteins Bax and Caspase 3 in plaques, while concurrently reducing the levels of Bcl-2. Notably, pre-treatment with Poly (I:C) counteracts this effect induced by P. gingivalis, resulting in decreased expression of Bax and Caspase 3 alongside an elevation in Bcl-2 levels compared to the P. gingivalis group. Poly (I:C), Polyinosinic-polycytidylic acid; P. gingivalis, P. gingivalis; PBS, Phosphate buffered saline; Bcl-2, B-Cell Lymphoma-2; Bax, Bcl2-associated x.