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. 2024 Oct 11;20(2):811–818. doi: 10.1016/j.jds.2024.09.021

Figure 4.

Figure 4

The pretreatment with Poly(I:C) affects the expression of JAK/STAT1 in HUVECs. (A, B) The expression levels of p–STAT1 and p-JAK1/2 in Poly (I:C) pretreaded-HUVECS were detected by Western blot. (C, D) Regardless of Fludarabine pretreatment, subsequent Poly (I:C) stimulation was employed to assess the expression levels of Caspase 3, Caspase 9, Bcl-2 and Bax proteins using Western blot analysis. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Poly (I:C), Polyinosinic-polycytidylic acid; P. gingivalis, P. gingivalis; PBS, Phosphate buffered saline; Bcl-2, B-Cell Lymphoma-2; Bax, Bcl2-associated x; STAT, signal transducer and activator of transcription; JAK, janus kinase; p- STAT, phosphor-STAT; p-JAK, phosphor-JAK; DMSO, Dimethyl sulfoxide.