Table 3.

Permutation Results at Linked and Unlinked Loci^[Note]

	PPL (%) for
Locus	Random Subsets [SD]	Pooled Data
1q23-24	2.1 [2.8]	1.7
Unlinked	.3 [.4]	1.2

Note.— Families were randomly permuted into six subsets, corresponding to the observed clinical subset sizes, and the PPL was sequentially updated across these random subsets. One thousand permutations were performed at each locus, and the average (SD) was calculated across permutations. PPLs for pooled data, shown for comparison, were computed by treating all six subsets as a single data set (i.e., without sequential updating across subgroups).