Table 2.
Resistance pattern of isoniazid, fluoroquinolone, aminoglycoside, and ethionamide among patients with pulmonary tuberculosis as determined by the gold standard Lowenstein–Jensen proportion method
| Resistance pattern | Total cases (n = 793) n (%) |
New cases (n = 611) n (%) |
Re-treated cases (n = 182) n (%) |
P value |
|---|---|---|---|---|
| All sensitive | 368 (46.4) | 423 (69.2) | 59 (32.4) | < 0.001 |
| All resistant | 4 (0.5) | 0 (0) | 4 (2.2) | < 0.001 |
| Any resistance | ||||
| INH | 284 (35.8) | 164 (26.8) | 120 (65.9) | < 0.001 |
| FLQ | 114 (14.4) | 67 (11.0) | 47 (25.8) | < 0.001 |
| AMG | 7 (0.9) | 0 (0) | 7 (3.8) | < 0.001 |
| ETH | 192 (24.2) | 149 (24.4) | 43 (23.6) | 0.825 |
| Mono-drug resistant | ||||
| INH | 140 (17.7) | 88 (14.4) | 52 (28.6) | < 0.001 |
| FLQ | 35 (4.4) | 29 (4.7) | 6 (3.3) | 0.418 |
| ETH | 100 (12.6) | 94 (15.4) | 6 (3.3) | < 0.001 |
| AMG | 0 (0) | 0 (0) | 0 (0) | – |
| Poly-drug resistant | ||||
| INH + FLQ | 55 (6.9) | 26 (4.3) | 29 (15.9) | < 0.001 |
| INH + FLQ + AMG | 2 (0.3) | 0 (0) | 2 (1.1) | 0.009 |
| INH + FLQ + ETH | 12 (1.5) | 7 (1.1) | 5 (2.7) | 0.115 |
| INH + ETH | 70 (8.8) | 43 (7.0) | 27 (14.8) | < 0.001 |
| FLQ + ETH | 6 (0.8) | 5 (0.8) | 1 (0.5) | 0.676 |
| INH + AMG | 1 (0.1) | 0 (0) | 1 (0.5) | 0.080 |
INH isoniazid, FLQ fluoroquinolones, AMG aminoglycoside, ETH ethionamide